Effects of guinea pig vasoactive intestinal peptide on the isolated perfused guinea pig heart

¹Department of Pharmacology, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37614.

|March 1, 1989

Abstract:

The pharmacological effects of guinea pig vasoactive intestinal peptide (VIP) were studied in isolated perfused guinea pig hearts. Bolus injections of VIP produced a dose-dependent tachycardia that was not affected by atenolol. A decrease in amplitude of ventricular contractions occurred in response to all doses of VIP. This response was preceded by a small increase in amplitude in 3 of 6 hearts at the highest dose. VIP produced a decrease in perfusion pressure which was prominent after coronary tone was elevated with [Arg8]-vasopressin. The present findings support speculation that VIP may have a role in the regulation of heart rate and coronary blood flow.

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Effects of guinea pig vasoactive intestinal peptide on the isolated perfused guinea pig heart

Abstract:

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