ICOS Co-Stimulation: Friend or Foe?
Daniel J Wikenheiser1, Jason S Stumhofer1
1Department of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, AR , USA.
Frontiers in Immunology
|August 26, 2016
Summary
The inducible T cell co-stimulator (ICOS) regulates T cell immunity and antibody responses. Modulating ICOS signaling offers potential therapeutic strategies for autoimmune disorders.
Area of Science:
- Immunology
- Molecular Biology
Background:
- The inducible T cell co-stimulator (ICOS) is crucial for adaptive immunity.
- ICOS influences T helper cell differentiation and antibody production.
Purpose of the Study:
- To summarize the role of ICOS in T cell immunity and antibody responses.
- To explore ICOS's involvement in infections and autoimmune diseases.
- To evaluate ICOS-targeted therapies.
Main Methods:
- Review of existing literature on ICOS function.
- Analysis of ICOS's role in T cell differentiation and germinal center reactions.
- Examination of ICOS's link to autoimmune disorders.
Main Results:
- ICOS regulates Th1, Th2, and Th17 cell differentiation.
- ICOS is essential for thymus-dependent antibody responses and germinal center formation.
- ICOS signaling impacts disease outcomes in various infections.
Conclusions:
- ICOS plays a complex role in adaptive immunity, influencing both T cell responses and antibody production.
- Targeting ICOS signaling presents a potential therapeutic avenue for autoimmune diseases.
Keywords:
T cell activationantibody productionco-stimulatory moleculesparasitic and bacterial infectionMore Related Videos
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