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T Cell Types and Functions

T Cell Types and Functions

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Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Histamine regulates murine primary dendritic cell functions.

Heiko Schenk¹, Detlef Neumann¹, Christina Kloth^1,2

¹a Institute of Pharmacology, Hannover Medical School , Hannover , Germany ;

Immunopharmacology and Immunotoxicology

|August 26, 2016

Summary

Histamine enhances dendritic cell (DC) antigen uptake and activation through histamine receptors 1, 2, and 4. This finding reveals histamine

Keywords:

Histamine activation antigen uptake dendritic cells

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Area of Science:

Immunology
Cell Biology

Background:

Histamine modulates immune responses.
Dendritic cells (DCs) are key antigen-presenting cells.

Purpose of the Study:

To investigate histamine's effect on murine DC antigen uptake and activation.
To identify histamine receptor subtypes involved.

Main Methods:

Murine splenic and lung DCs were isolated and stimulated with histamine.
Antigen uptake and co-stimulatory molecule expression (CD80, CD86, ICOS-L) were measured by flow cytometry.
Histamine receptor antagonists (H1R, H2R, H4R) were used to determine receptor involvement.

Main Results:

Histamine accelerated antigen uptake in DCs via H1R, H2R, and H4R.
Histamine enhanced CD86 and ICOS-L expression, but not CD80.
Blocking H1R, H2R, and H4R reduced histamine-induced co-stimulatory molecule expression.

Conclusions:

Histamine regulates the immunological synapse.
Histamine stimulates DC antigen uptake and activation through H1R, H2R, and H4R.