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Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis?
Duygu Tecer1, Melek Sezgin2, Arzu Kanık3
1Department of Physical Medicine & Rehabilitation, Division of Rheumatology, Gazi University Medical Faculty, Ankara, Turkey.
Aim:
To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA).
Patients & Methods:
Hundred RA and 100 controls were included.
Results:
MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 and 10.4. Patients with RDW >14.8 had higher Disease Activity Score 28 (DAS28; p = 0.002) and pain score (p = 0.0007). RDW was positively correlated with DAS28 and pain. But, DAS28 and pain were not different between patients with MPV >10.4 and <10.4.
Conclusion:
MPV and RDW were significantly higher in RA. RDW and MPV were similar to erythrocyte sedimentation rate and C-reactive protein to indicate inflammatory activity. RDW was correlated with pain and DAS28, but MPV was not associated with them.
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