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Related Experiment Video

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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
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Chest wall Ewing sarcoma: a population-based analysis.

Andrew J Jacobs1, Joanna Fishbein2, Carolyn Fein Levy3

  • 1Hofstra Northwell School of Medicine, 500 Hofstra University, Hempstead, New York.

The Journal of Surgical Research
|August 28, 2016
PubMed
Summary
This summary is machine-generated.

Pediatric chest wall Ewing sarcoma (CWES) survival has improved significantly, with increased surgery and decreased radiation. Female patients and those without metastatic disease have better prognoses in this rare cancer.

Keywords:
ChestEwingSEERSarcoma

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Area of Science:

  • Pediatric Oncology
  • Sarcoma Research
  • Cancer Epidemiology

Background:

  • Chest wall Ewing sarcoma (CWES) is a rare pediatric cancer with limited research due to low incidence.
  • Previous studies were primarily small, single-institution reviews.

Purpose of the Study:

  • To conduct a population-based analysis of CWES.
  • Assess incidence, demographics, treatment patterns, and long-term survival.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1973-2011).
  • Identified 193 pediatric patients (0-21 years) with CWES.
  • Analyzed survival trends, treatment changes (radiation, surgery), and prognostic factors using Kaplan-Meier curves and Cox regression.

Main Results:

  • Overall survival (OS) improved from 38% (1973-1979) to 65% (2000-2011).
  • Radiation use decreased (84% to 40%), while surgery rates increased (75% to 85%).
  • Male sex (HR: 2.4) and metastatic disease at presentation (37%) were associated with higher mortality.

Conclusions:

  • Significant improvements in pediatric CWES survival observed over four decades.
  • Shifting treatment paradigms include decreased radiation and increased surgical intervention.
  • Female gender and non-metastatic disease are favorable prognostic indicators for CWES.