Prevalence of oral allergy syndrome in children with allergic diseases

Related Experiment Video

Updated: Mar 15, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.8K

M Bedolla-Barajas1, A Kestler-Gramajo2, G Alcalá-Padilla3

  • 1Servicio de Alergia e Inmunología Clínica, Nuevo Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Salvador de Quevedo y Zubieta No. 750, Colonia La Perla, Guadalajara, Jalisco, C. P. 44340, Mexico.

Allergologia Et Immunopathologia
|August 28, 2016
PubMed

Insights

Oral Allergy Syndrome (OAS) affects nearly 9% of children with allergic diseases. This study found pineapple sensitivity and Quercus pollen are linked to OAS in this population.

Area of Science:

  • Pediatric Allergy and Immunology
  • Food Allergy Research
  • Clinical Immunology

Background:

  • Oral Allergy Syndrome (OAS) is often perceived as an adult condition, with limited exploration in pediatric populations.
  • This study addresses the under-investigated prevalence and characteristics of OAS in children with existing allergic conditions.

Purpose of the Study:

  • To determine the prevalence of OAS in children aged 6-14 years with allergic diseases.
  • To identify common symptoms and associated pollen species linked to OAS in this pediatric cohort.
  • To investigate the association between specific pollen sensitizations and the development of OAS.

Main Methods:

  • A cross-sectional study involving 267 children (6-14 years) seeking initial allergy treatment.
  • Data collected via structured questionnaires on demographics, clinical history, and OAS.
  • Skin prick-by-prick tests used to confirm allergen sensitization, particularly for foods implicated in OAS.
  • Logistic regression analysis employed to assess the association between OAS, pollen sensitization, and demographic factors.

Main Results:

  • The overall prevalence of OAS was 8.9%, with similar rates in children with allergic rhinitis (8.8%) and asthma (9.1%).
  • Prevalence of OAS varied from 9.6% to 12.2% among children sensitized to different pollens.
  • Pineapple sensitivity was reported in 62.5% of children with OAS.
  • Quercus species pollen demonstrated a significant association with OAS (OR=2.7) after adjusting for covariates.

Conclusions:

  • Oral Allergy Syndrome is a relevant condition in the pediatric population studied.
  • Pineapple emerged as the primary food allergen associated with OAS in this region.
  • Sensitization to Quercus pollen, but not birch or olive pollen, was significantly linked to OAS in children.
Abstract

Keywords:
ChildCross-reactionsFood hypersensitivityPollenRisk factors

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.9K
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children10:42

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

18.0K

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
111
Allergic Reactions02:06

Allergic Reactions

Overview
33.3K
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.2K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
91
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
119