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Related Experiment Video

Updated: Mar 15, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Pregnancy and acromegaly.

Ammar Muhammad1, Sebastian J Neggers1, Aart J van der Lely2,3

  • 1Rotterdam Pituitary Centre, Erasmus University MC, Rotterdam, The Netherlands.

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|August 29, 2016
PubMed
Summary

Pregnancy in women with acromegaly is rare but manageable. While medical treatments for growth hormone (GH) excess appear safe, it is recommended to halt interventions during pregnancy due to limited data.

Keywords:
AcromegalyComplicationsPregnancyReviewTreatment

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Area of Science:

  • Endocrinology
  • Reproductive Medicine

Background:

  • Acromegaly, a rare disorder of excess growth hormone (GH), often presents with secondary hypogonadism, making pregnancy infrequent.
  • Despite rarity, pregnancies in acromegalic women raise clinical questions regarding management, potential complications, and necessary follow-up care.

Purpose of the Study:

  • To provide practical information and address key issues concerning pregnancy in women with acromegaly.
  • To review current understanding of hormonal changes and management strategies during pregnancy in acromegalic patients.

Main Methods:

  • This review synthesizes existing published literature on acromegaly and pregnancy.

Main Results:

  • Hormonal interplay involving GH, IGF-1, and insulin is crucial in pregnancy, with fetal-placental units partially regulating these in acromegaly.
  • Existing data suggest dopamine agonists, somatostatin analogs, and GH receptor antagonists may not pose adverse risks to mother or fetus when used during pregnancy.

Conclusions:

  • Medical interventions for acromegaly during pregnancy are generally advised to be discontinued due to insufficient safety data.
  • Tumor activity and size typically do not escalate during pregnancy, often negating the need for medical treatment.