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Myopericytoma - a unifying term or a unique entity?
Z S Jairajpuri1, M J Hasan, G B Madan
1Hamdard Institute of Medical Sciences and Research, Department of Pathology, Jamia Hamdard, New Delhi, India. sujatajetley@gmail.com.
The Malaysian Journal of Pathology
|August 30, 2016
Summary
Myopericytoma, a rare benign tumor, presents as a slow-growing nodule. Immunohistochemistry confirmed its origin from perivascular myoid cells, aiding diagnosis.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Myopericytoma are uncommon, benign perivascular neoplasms characterized by a hemangiopericytoma-like vascular pattern.
- They are recognized by the World Health Organization as a distinct disease entity.
Observation:
- A case report details a 52-year-old male with a 9-month history of a painless, palpable nodule on the left thumb.
- The 15x12mm mass, located on the thenar aspect, showed soft tissue swelling on X-ray without bony involvement.
Findings:
- Histopathological examination revealed a non-encapsulated, well-circumscribed neoplasm with spindle to ovoid cells and a perivascular arrangement.
- Tumor cells exhibited diffuse smooth muscle actin positivity and negative staining for CD34 and desmin.
- Absence of nuclear atypia, mitotic figures, and necrosis was noted.
Implications:
- Immunohistochemical findings support the origin of myopericytoma from perivascular myoid cells.
- Distinguishing myopericytoma from similar neoplasms like hemangiopericytoma, glomus tumors, myofibroma, and solitary fibrous tumors is crucial.
- Accurate diagnosis is essential for appropriate management of this rare tumor.
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