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Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
Published on: August 16, 2012
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Layer-by-Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface
Anna Polomska1, Jean-Christophe Leroux1, Davide Brambilla1
1Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich (ETHZ), Vladimir-Prelog Weg 1-5/10, 8093, Zurich, Switzerland.
Macromolecular Bioscience
|August 30, 2016
Summary
Layer-by-layer coating offers versatile control over drug release from colloidal particles. This review details fabricating drug-only cores and multilayer shells for optimized drug delivery systems.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Layer-by-layer (LbL) coating is a versatile technique for sequential deposition of materials.
- LbL's relevance in drug delivery stems from precise control over cargo release from colloidal systems.
Purpose of the Study:
- This review focuses on LbL encapsulation of colloidal particles composed entirely of drug.
- It covers core fabrication, coating strategies, shell permeability, and delivery outcomes.
Main Methods:
- Fabrication of drug-only colloidal cores.
- Sequential deposition of polyelectrolytes or other materials for multilayer shell formation.
- Characterization of shell permeability and drug release kinetics.
Main Results:
- LbL enables fine-tuning of drug release rates through multilayer shell design.
- Successful encapsulation of various drugs within colloidal particles.
- Demonstrated control over in vitro and in vivo drug delivery profiles.
Conclusions:
- LbL encapsulation of drug-only cores is a promising strategy for advanced drug delivery.
- The technique offers tunable release kinetics and versatile application potential.
- Further research can optimize LbL systems for targeted and sustained drug release.
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