Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.5K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.9K
5.9K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.6K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.6K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

11.2K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
11.2K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

9.4K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
9.4K
Tumor Progression02:07

Tumor Progression

7.8K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid Cementation Technique Using the New Modular System for Aseptic Knee Arthroplasty Revision Surgery.

The archives of bone and joint surgery·2022
Same author

Early results with a bicruciate-retaining total knee arthroplasty: a match-paired study.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2020
Same author

Guidelines for Resuming Elective Hip and Knee Surgical Activity Following the COVID-19 Pandemic: An Italian Perspective.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery·2020
Same author

Humeral head necrosis associated to shaft non-union with massive bone loss: a case report.

Acta bio-medica : Atenei Parmensis·2020
Same author

Autologous adipose stem cell therapy for knee osteoarthritis: where are we now?

The Physician and sportsmedicine·2020
Same author

Non artheritic bilateral anterior ischaemic optic neuropathy (NAION) as devastating complication following Total Hip Arthroplasty: a case report.

Acta bio-medica : Atenei Parmensis·2020

Related Experiment Video

Updated: Mar 15, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.5K

Synovial chondrosarcoma.

Alessio Biazzo1, Norberto Confalonieri1

  • 1Orthopaedic Department, ASST Gaetano Pini-CTO, via Bignami 1, Milano, Italy.

Annals of Translational Medicine
|August 30, 2016
PubMed
Summary

Synovial chondrosarcoma (SCH), a rare intra-articular tumor, often arises from pre-existing synovial chondromatosis (SC). This review highlights its poor prognosis, emphasizing the need for prompt diagnosis and specialized treatment.

Area of Science:

  • Orthopedic Oncology
  • Pathology
  • Radiology

Background:

  • Synovial chondrosarcoma (SCH) is an exceptionally rare tumor originating within joint cavities.
  • It is frequently considered a malignant progression of pre-existing synovial chondromatosis (SC).

Purpose of the Study:

  • To systematically review primary and secondary SCH cases from existing literature.
  • To consolidate data from case reports and series to summarize general characteristics of this rare disease.

Main Methods:

  • A systematic review of 42 abstracts (case series and reports) detailing 67 SCH cases was conducted.
  • Inclusion criteria required histological confirmation of SCH, primary or secondary, with or without prior SC.

Main Results:

Keywords:
Synovial chondrosarcoma (SCH)malignant transformationsynovial chondromatosis (SC)synovial tumor

More Related Videos

Synovial Fluid Analysis to Identify Osteoarthritis
07:51

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

6.9K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.7K

Related Experiment Videos

Last Updated: Mar 15, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.5K
Synovial Fluid Analysis to Identify Osteoarthritis
07:51

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

6.9K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.7K
  • The average age of patients was 56.9 years, with a male predominance.
  • The knee was the most affected joint (47.7%), followed by the hip (34.3%).
  • Amputation was the surgical outcome in 59.7% of cases, with a local recurrence rate of 28.3%.

Conclusions:

  • SCH carries a worse prognosis than conventional sarcomas, attributed to its intra-articular location, diagnostic delays, and inadequate prior treatments.
  • Rapid deterioration of SC or post-synoviectomy recurrence warrants suspicion of malignant transformation and referral to a specialized center.