Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highlighting the value of polymyography in childhood onset movement disorders.

Frontiers in neurology·2026
Same author

Socio-Demographic and Health Data of Adolescents Identifying as Transgender or Gender Diverse in the Born in Bradford's Age of Wonder Cohort.

Wellcome open research·2026
Same author

From waitlists to clinical action: pathway development and research priorities in childhood developmental regression.

The Lancet. Child & adolescent health·2026
Same author

Use of High-Efficacy Therapy in Children With Multiple Sclerosis to Prevent Long-Term Disability.

Neurology·2026
Same author

French NOMADMUS Cohort Overview: Landscape Evolution of AQP4+NMOSD and MOGAD From 2010 to 2024.

Neurology·2026
Same author

Descriptive Epidemiology of Pediatric Autoimmune Diseases of the Central Nervous System in the Afro-Descendant Population of the Caribbean Island of Martinique.

Pediatric neurology·2026
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Related Experiment Video

Updated: Mar 15, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

949

Pediatric transverse myelitis.

Michael Absoud1, Benjamin M Greenberg2, Ming Lim2

  • 1From Children's Neurosciences (M.A., M.L.), Evelina London Children's Hospital at Guy's & St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK; Department of Neurology and Neurotherapeutics and Department of Pediatrics (B.M.G.), UT Southwestern and Childrens Health, Dallas, TX; Division of Child Neurology (T.L.), Baylor College of Medicine, Houston, TX; Texas Children's Hospital (T.L.), Houston, TX; Neurology Service (T.T.), Department of Paediatrics, KK Women's and Children's Hospital, Singapore; and Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Pediatric Neurology Department, National Referral Center for Neuro-Inflammatory Diseases in Children, and University Paris Sud (K.D.), Le Kremlin-Bicêtre, France. michael.absoud@gstt.nhs.uk.

Neurology
|August 31, 2016
PubMed
Summary
This summary is machine-generated.

Pediatric acute transverse myelitis (ATM) is an immune disorder affecting the CNS in children. While outcomes are generally better than in adults, more research is needed for optimal treatment and standardized care.

More Related Videos

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.8K
Mouse Models of Periventricular Leukomalacia
06:24

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

30.5K

Related Experiment Videos

Last Updated: Mar 15, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

949
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.8K
Mouse Models of Periventricular Leukomalacia
06:24

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

30.5K

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Pediatric acute transverse myelitis (ATM) is an immune-mediated central nervous system (CNS) disorder.
  • It accounts for 20% of acquired demyelinating syndromes (ADS) in children.
  • ATM requires differentiation from other myelopathies and can be an initial presentation of relapsing ADS like NMO or MS.

Purpose of the Study:

  • To review current knowledge on clinical features, diagnostics, pathogenesis, and management of pediatric ATM.
  • To highlight the need for standardized protocols for clinical assessment and investigation.
  • To suggest future research directions for understanding prognostic factors and optimizing treatment.

Main Methods:

  • Review of existing literature on pediatric acute transverse myelitis.
  • Analysis of diagnostic criteria and their application in children.
  • Examination of MRI findings, including lesion characteristics and location.
  • Discussion of the role of antibodies like MOG in ATM pathogenesis and treatment.

Main Results:

  • Diagnostic criteria for ATM can be applied to children, though sensory levels may be less evident.
  • MRI often shows centrally located lesions involving gray and white matter, with longitudinally extensive ATM being common.
  • Asymptomatic brain MRI lesions are present in over one-third of cases and predict MS or NMO.
  • Children generally experience better outcomes than adults, with 50% recovering fully within 2 years.

Conclusions:

  • Pediatric ATM is a significant condition with variable outcomes and substantial healthcare demands.
  • Further research, including standardized international collaborative studies, is essential to identify prognostic factors for disability and relapse.
  • There is a lack of robust controlled trials to guide optimal treatment strategies for ATM in both children and adults.