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IgA Nephropathy in Children: A Multicenter Study in Poland
M Mizerska-Wasiak1, A Turczyn2, A Such2
1Department of Pediatrics and Nephrology, Medical University of Warsaw, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland. wasiaczki@wp.pl.
Advances in Experimental Medicine and Biology
|August 31, 2016
Summary
IgA nephropathy (IgAN) is a common kidney disease in children. Early detection through regular urine tests, especially after infections, is crucial for identifying this insidious condition.
Area of Science:
- Pediatric Nephrology
- Glomerulonephritis Research
- Renal Pathology
Background:
- IgA nephropathy (IgAN) is the most frequent glomerulonephritis in children.
- Disease presentation varies from microscopic hematuria to end-stage kidney disease.
- Understanding pediatric IgAN clinical and pathological features is vital for prognosis.
Purpose of the Study:
- To retrospectively analyze clinical and kidney biopsy data in pediatric IgAN patients.
- To identify risk factors and disease progression markers in children with IgAN.
- To establish the incidence and characteristics of IgAN in the Polish pediatric population.
Main Methods:
- Retrospective assessment of 140 pediatric IgAN patients (2000-2015) from a national registry.
- Analysis included proteinuria, hematuria, GFR, blood pressure, and Oxford classification/crescent scores.
- ROC analysis determined age cut-off for GFR <90 mL/min/1.73 m² (13.9 years).
Main Results:
- Incidence of IgAN in Poland: 9.3 new cases/year.
- Mean age at onset: 11.9 years; nephritic syndrome in 52% of patients.
- Older age at onset (>13.9 years) correlated with more severe pathological lesions (S1, T1-2, crescents) despite shorter time to biopsy.
Conclusions:
- Pediatric IgA nephropathy can present insidiously.
- Early detection via regular urinalysis, particularly post-respiratory infection, is recommended.
- Age at onset is a significant factor associated with disease severity in children.
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