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Pancreatic disorders in inflammatory bowel disease
Filippo Antonini1, Raffaele Pezzilli1, Lucia Angelelli1
1Filippo Antonini, Giampiero Macarri, Department of Gastroenterology, A.Murri Hospital, Polytechnic University of Marche, 63900 Fermo, Italy.
World Journal of Gastrointestinal Pathophysiology
|August 31, 2016
Summary
Patients with inflammatory bowel disease (IBD) have a higher risk of pancreatic disorders, including acute and chronic pancreatitis. Some cases suggest direct pancreatic damage, potentially missed due to similar symptoms.
Area of Science:
- Gastroenterology
- Internal Medicine
- Pancreatology
Background:
- Patients with inflammatory bowel disease (IBD) exhibit a higher incidence of pancreatic disorders than the general population.
- Pancreatitis in IBD patients is often linked to gallstones or medications, but idiopathic cases suggest direct pancreatic involvement.
- Overlapping symptoms between IBD and pancreatic diseases can lead to underdiagnosis of pancreatic conditions in IBD patients.
Purpose of the Study:
- To review the spectrum of pancreatic diseases observed in individuals diagnosed with inflammatory bowel disease (IBD).
- To highlight the diagnostic challenges and potential direct pancreatic damage associated with IBD.
Main Methods:
- Literature review of studies investigating pancreatic disorders in IBD patients.
- Analysis of reported cases and etiological factors for pancreatitis in IBD.
Main Results:
- Increased prevalence of both acute and chronic pancreatitis in IBD cohorts.
- Identification of biliary lithiasis and drug induction as common causes, alongside idiopathic pancreatitis.
- Recognition of symptom overlap complicating diagnosis.
Conclusions:
- Inflammatory bowel disease is associated with an increased risk of pancreatitis.
- Idiopathic pancreatitis in IBD may indicate direct pancreatic injury.
- Awareness and diagnostic vigilance are crucial for recognizing pancreatic diseases in IBD patients.
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