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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Updated: Jul 4, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Appendix in ulcerative colitis pathogenesis and therapy: An updated narrative review.

Omar AbdelGhani1, Sherreen Elhariri2, Payal Bhatnagar3

  • 1Department of Surgery, Ministry of Health and Population, Cairo, 11737, Egypt.

World Journal of Gastrointestinal Pathophysiology
|July 3, 2026
PubMed
Summary
This summary is machine-generated.

Ulcerative colitis (UC) involves chronic colon inflammation. Early appendectomy may reduce UC risk and improve remission, positioning it as a potential therapeutic strategy.

Keywords:
AutophagyImmune dysregulationTherapeutic appendectomyUlcerative colitisXenophagy

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Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes
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08:52

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Published on: February 5, 2021

Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory colon disorder.
  • Pathogenesis involves genetic, immune, microbiome, and environmental factors.
  • Autophagy dysfunction may compromise the intestinal barrier and microbial clearance in UC.

Purpose of the Study:

  • To summarize current evidence on UC pathogenesis and risk factors.
  • To explore the emerging role of the appendix in UC.
  • To review the therapeutic potential of appendectomy for UC.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of epidemiological data.
  • Consideration of recent clinical trial findings (ACCURE 2025, COSTA 2026).

Main Results:

  • The appendix may act as a critical priming site for UC.
  • Appendectomy shows an inverse association with UC risk.
  • Clinical trials suggest improved remission outcomes post-appendectomy in selected UC patients.

Conclusions:

  • The appendix is an immunological and microbial hub.
  • Appendectomy is a potential adjunctive treatment for UC.
  • Further mechanistic and clinical research on appendectomy for UC is warranted.