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Glycan Node Analysis: A Bottom-up Approach to Glycomics
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Glycosylation in Cancer Medicines Delivery and Their Patents

Biswa Mohan Sahoo1, Shikha Sharma2, Payal Bhatnagar3

  • 1Department of Pharmaceutical Science, School of Pharmacy and Life Sciences, Centurion University of Technology & Management, Jatni, Bhubaneswar, Khurda, 752050, Odisha, India.

Current Drug Delivery
|April 1, 2026
PubMed

Insights

Glycosylation is key in cancer, influencing progression and treatment. Glycosylation-mediated drug delivery offers targeted cancer therapies, improving efficacy and reducing toxicity.

Area of Science:

  • Oncology
  • Biochemistry
  • Drug Delivery

Background:

  • Glycosylation significantly impacts cancer pathophysiology, affecting tumor progression, metastasis, immune evasion, and drug resistance.
  • Altered glycosylation patterns in tumors are crucial biomarkers and therapeutic targets for improved cancer diagnostics and treatments.
  • Glycosylation-mediated drug delivery systems (DDSs) enhance tumor cell targeting via receptor interactions, increasing drug efficacy and minimizing systemic toxicity.

Purpose of the Study:

  • To review recent advances in glycosylation-mediated drug delivery for cancer treatment.
  • To synthesize research and patents on glycosylation's role in cancer biology and targeted therapeutics.
  • To identify trends, challenges, and future directions in glycosylation-based cancer drug delivery.

Main Methods:

  • Narrative review synthesizing peer-reviewed articles and patents from 2020-2025.
  • Searched databases (European, Google Patents, Lens.org) using keywords: cancer, glycosylation, drug, medicine, oncology.
  • Qualitative synthesis and categorization of findings by therapeutic approach, target, and development stage.

Main Results:

  • Glycosylated nanocarriers, antibodies, and fusion proteins show promise in anticancer therapies by enhancing drug stability, cellular uptake, and immune modulation.
  • Recent patents highlight innovations in glycosylation for improved drug targeting and efficacy, particularly against multidrug resistance in lung, breast, and prostate cancers.
  • Glycosylation influences cancer metastasis, immune evasion, metabolism, ferroptosis, and senescence, offering multifaceted therapeutic targets.

Conclusions:

  • Glycosylation is a critical factor in cancer biology with significant potential for targeted diagnostics and therapeutics.
  • Glycosylation-based drug delivery systems represent a promising strategy for personalized cancer medicine.
  • Further research and development in glycosylation-mediated DDSs are essential for clinical translation and improved cancer patient outcomes.
Keywords:
Glycosylationcancer nanomedicinecancer therapycellular senescencegalectin receptors.glycosylated drug delivery systemsimmunitylectin-mediated targetingtumor biomarkerstumor-targeted therapy

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