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Updated: Mar 15, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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PCSK9: Regulation and Target for Drug Development for Dyslipidemia

Amy C Burke1, Jacqueline S Dron1, Robert A Hegele1,2

  • 1Department of Biochemistry, Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7; email: aburke42@uwo.ca , jdron@uwo.ca , hegele@robarts.ca , mhuff@uwo.ca.

Annual Review of Pharmacology and Toxicology
|August 31, 2016
PubMed

Keywords:
PCSK9 inhibitorscardiovascular diseaselow-density lipoprotein cholesterollow-density lipoprotein receptorproprotein convertase subtilisin/kexin type-9

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