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Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A
Ruofei Trophy Chen1, Adam J Nelson1, Sophia Zoungas2
1Monash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Diabetes, Obesity & Metabolism
|July 8, 2026
Summary
Cardiovascular risk in type 2 diabetes is diverse. Integrating anatomical imaging and genetic profiling offers a more comprehensive risk assessment than single methods alone.
Area of Science:
- Cardiology
- Genetics
- Radiology
Background:
- Type 2 diabetes (T2D) is associated with increased cardiovascular disease (CVD) risk.
- Current risk stratification methods may not fully capture individual CVD risk in T2D patients.
Purpose of the Study:
- To characterize baseline clinical, anatomical, and genetic cardiovascular risk profiles in T2D patients.
- To examine the concordance between these different risk domains.
Main Methods:
- Analysis of 126 T2D participants from the VOLTAIRE study.
- Coronary atherosclerosis assessed via coronary artery calcium (CAC) score and CT angiography (CTCA).
- Clinical risk evaluated using the NZSSD risk calculator; genetic risk assessed using polygenic risk scores (PRS).
Main Results:
- High heterogeneity in coronary atherosclerotic burden observed (CAC=0 in 34.9%, CAC≥400 in 19.8%).
- Moderate-to-severe stenosis (≥50%) present in 40.5%, including 20.4% of low clinical risk individuals.
- Limited overlap (8.7%) in participants classified as high risk across clinical, anatomical, and genetic domains.
Conclusions:
- Significant heterogeneity exists in cardiovascular risk assessment for T2D patients.
- Limited concordance between clinical, anatomical, and genetic risk factors necessitates a multimodal approach.
- Integrating imaging and genetic profiling enhances cardiovascular risk assessment in T2D.
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