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Updated: Mar 15, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Novel peer review method for improving controlled substance prescribing in primary care
Brian Penti1, Jane M Liebschutz2, Brian Kopcza3
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts.
Peer feedback using a chart review tool (CRT) reduced opioid prescribing in an urban family medicine clinic. This quality improvement project demonstrated a decrease in opioid dosage and successfully tapered some patients off medication.
Area of Science:
- Primary Care
- Quality Improvement
- Pain Management
Background:
- Opioid prescribing for chronic noncancer pain presents challenges in outpatient settings.
- Urban safety-net teaching hospitals face unique demands in managing pain and prescribing controlled substances.
Purpose of the Study:
- To evaluate the impact of a chart review tool (CRT) providing peer feedback on opioid prescribing practices.
- To assess opioid prescribing patterns in an urban family medicine clinic.
Main Methods:
- A 1-year quality improvement project was conducted in an outpatient family medicine clinic.
- A CRT was implemented for physicians to provide peer feedback on opioid prescribing.
- Physician opioid prescribing practices were compared pre- and post-intervention.
Main Results:
- Sixty percent of reviewed patient charts showed policy violations, often linked to missed specialist appointments.
- The mean opioid dose decreased by 2.6 mg morphine equivalent dose (MED)/day post-intervention, contrasting a prior increase of 6.9 mg MED/day.
- Sixteen percent of patients prescribed opioids were successfully taken off the medication.
Conclusions:
- Implementing a CRT for peer feedback offers valuable insights into opioid prescribing.
- This approach shows promise for enhancing the quality of opioid prescribing in urban primary care settings.
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