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Updated: Mar 15, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Theoretical Foundations for Evidence-Based Health Informatics: Why? How?
Philip J Scott1, Andrew Georgiou2, Hannele Hyppönen3
1Centre for Healthcare Modelling and Informatics, University of Portsmouth, Hampshire, United Kingdom.
Abstract:
A scientific approach to health informatics requires sound theoretical foundations. Health informatics implementation would be more effective if evidence-based and guided by theories about what is likely to work in what circumstances. We report on a Medinfo 2015 workshop on this topic jointly organized by the EFMI Working Group on Assessment of Health Information Systems and the IMIA Working Group on Technology Assessment and Quality Development. We discuss the findings of the workshop and propose an approach to consolidate empirical knowledge into testable middle-range theories.
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