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Related Concept Videos

Genomics02:02

Genomics

41.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

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Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

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Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
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The Genomic Medicine Game.

Elvis Tran1, Enrique J de Andrés-Galiana2, Sonia Benitez3

  • 1Health and Biomedical Informatics Centre, The University of Melbourne, Melbourne, Victoria, Australia.

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Summary

Genomic medicine education is enhanced by a new game, the Genomic Medicine Game, which helps users understand complex genotype-phenotype relationships. This educational tool was developed using literature reviews and tested successfully.

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Area of Science:

  • Genomics
  • Medical Education
  • Bioinformatics

Background:

  • Advancements in genomics technology are transforming healthcare, leading to new medical paradigms like genomic medicine.
  • Current educational approaches for clinicians, researchers, and students often lag behind these rapid advancements.
  • A gap exists in effectively training professionals to navigate the complexities of genomic medicine.

Purpose of the Study:

  • To develop an educational tool, the Genomic Medicine Game, to conceptualize key components of genomic medicine.
  • To address the educational deficit in genomic medicine by providing an engaging learning experience.
  • To facilitate understanding of phenotype-genotype associations within the context of genomic medicine.

Main Methods:

  • Conducted a literature review to identify key phenotype-genotype associations relevant to genomic medicine.
  • Developed the Genomic Medicine Game using the Java programming language.
  • Designed the game to focus on core concepts derived from the literature review.

Main Results:

  • The Genomic Medicine Game was successfully built and implemented.
  • Initial testing of the game yielded promising results, indicating its educational potential.
  • The game effectively conceptualizes key components of genomic medicine for users.

Conclusions:

  • The Genomic Medicine Game serves as a valuable educational tool for understanding genomic medicine.
  • The game successfully bridges the gap between genomic advancements and professional education.
  • Further development and implementation of the game can significantly enhance genomic medicine training.