Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 15, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

13.2K

Cholestatic Itch Management.

Asit Mittal1

  • 1Department of Dermatology, RNT Medical College and Associate Hospitals, Udaipur, India.

Current Problems in Dermatology
|September 1, 2016
PubMed
Summary
This summary is machine-generated.

Cholestatic itch, a debilitating symptom of liver disease, may be caused by lysophosphatidic acid. Current treatments offer limited relief, necessitating research into novel therapies for this common condition.

Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

456
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
456
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

895
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
895
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

607
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
607
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.1K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.1K
Hand hygiene01:23

Hand hygiene

6.4K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
6.4K
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

1.6K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Demographic and Biochemical Profile of Patients with Premature Graying of Hair (Canities) at a Tertiary Care Centre: A Case-Control Study.

Indian dermatology online journal·2026
Same author

Expert Consensus on the Rational Approach to Isotretinoin Usage for Effective Management of Acne: ERAISE ACNE Recommendations.

Dermatology and therapy·2026
Same author

Response to Letter to the Editor: Addressing Concerns Regarding High-Dose Cyclosporine in Chronic Spontaneous Urticaria.

Indian dermatology online journal·2025
Same author

Eosinophilic Dermatosis of Hematological Malignancy.

Indian dermatology online journal·2025
Same author

Construction and Validation of a Novel "Pruritus Impact Scale" (PIS) for Assessment of Chronic Pruritus.

Indian dermatology online journal·2025
Same author

Real-World Clinical Experience with Oral Cyclosporine in Antihistamine Refractory Cases of Chronic Spontaneous Urticaria.

Indian dermatology online journal·2024
Same journal

Microblading Technique for Tattooing of "Hairstrokes" That Simulate Natural Hair: Eyebrow Tattooing and Correction of Medical Conditions.

Current problems in dermatology·2023
Same journal

Preface.

Current problems in dermatology·2023
Same journal

On the Use, Effectiveness, and Safety of Face Masks, Gloves, and Disinfectants to Prevent Transfer of Microbials between the Tattooist and the Customer: A Practical Review of Pros and Cons Including the Occupational Safety of the Tattooist.

Current problems in dermatology·2023
Same journal

Linearity and Surface Anatomy of the Face: From Embryo to Senescence.

Current problems in dermatology·2023
Same journal

Stretch Mark Treatment by Tattooing and Microneedling.

Current problems in dermatology·2023
Same journal

Auxiliary Utensils in Cosmetic and Medical Tattoo Settings.

Current problems in dermatology·2023
See all related articles

Area of Science:

  • Hepatology
  • Gastroenterology
  • Dermatology

Background:

  • Cholestatic itch significantly impacts patient quality of life.
  • Numerous hepatobiliary disorders present with cholestatic itch.
  • The exact pathogenesis of cholestatic itch remains unclear, despite implicated pruritogens like bile salts and histamine.

Purpose of the Study:

  • To review the current understanding of cholestatic itch pathogenesis.
  • To discuss existing and experimental treatment options for cholestatic itch.
  • To highlight the need for novel therapeutic strategies.

Main Methods:

  • Literature review of cholestatic itch research.
  • Analysis of implicated pruritogens and their roles.
  • Overview of current and experimental treatments.

More Related Videos

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

55.1K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.3K

Related Experiment Videos

Last Updated: Mar 15, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

13.2K
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

55.1K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.3K

Main Results:

  • Lysophosphatidic acid and autotaxin are emerging as key players in cholestatic itch pathogenesis.
  • Current treatments including cholestyramine, ursodeoxycholic acid, rifampicin, naltrexone, and sertraline have varying efficacy.
  • Interventional and experimental therapies like albumin dialysis and UVB phototherapy exist for refractory cases.

Conclusions:

  • Further research into the mechanisms of cholestatic itch is crucial.
  • Development of targeted therapies for cholestatic itch is needed.
  • Lysophosphatidic acid pathways represent a promising target for future drug development.