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Microfluidic tools toward industrial biotechnology.

Aline F Oliveira1, Amanda C S N Pessoa1, Reinaldo G Bastos2

  • 1Department of Bioprocesses and Materials Engineering, School of Chemical Engineering, University of Campinas, 500 Albert Einstein avenue, Campinas, P.O. Box 6066.

Biotechnology Progress
|September 1, 2016
PubMed
Summary

Microfluidics offers advanced tools for industrial biotechnology, enabling precise control over small fluid volumes for cell and enzyme studies. This technology optimizes bioprocesses through cell screening and biocatalyst encapsulation.

Keywords:
concentration gradient generatordroplet-basedindustrial biotechnologymicrobioreactormicrofluidics

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Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Microfluidics

Background:

  • Microfluidics enables the manipulation of small fluid volumes, facilitating the study of cells, enzymes, and biomolecules.
  • Conventional methods have limitations in controlling experimental conditions for biocatalyst encapsulation and analysis.

Purpose of the Study:

  • To review microfluidic technologies applicable to industrial biotechnology.
  • To explain fundamental microfluidic concepts and advanced approaches.
  • To highlight the potential of specific microfluidic tools in bioprocess development.

Main Methods:

  • Review of existing literature on microfluidic applications in biotechnology.
  • Discussion of concentration gradient generators, droplet-based microfluidics, and microbioreactors.
  • Exploration of technological possibilities and fundamental aspects of microfluidic parameters.

Main Results:

  • Microfluidic tools like gradient generators, droplet systems, and microbioreactors offer enhanced control and efficiency.
  • These technologies facilitate cell screening, biocatalyst encapsulation, and kinetic parameter determination.
  • Potential for commercial platforms in optimizing bioprocess development.

Conclusions:

  • Microfluidics presents significant opportunities for advancing industrial biotechnology.
  • Specific microfluidic approaches are valuable for optimizing bioprocesses and enabling new applications.
  • The technology allows for greater versatility in experimental conditions compared to traditional methods.