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Updated: Mar 15, 2026
Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Role of milk fat globule-epidermal growth factor 8 in osteoimmunology
Kathrin Sinningen1, Sylvia Thiele2, Lorenz C Hofbauer3
1Department of Obstetrics and Gynecology, Heinrich Heine University Düsseldorf , Düsseldorf, Germany.
Abstract:
Milk fat globule-epidermal growth factor 8 (MFG-E8) is a glycoprotein that is abundantly expressed in various tissues and has a pivotal role in the phagocytic clearance of apoptotic cells. However, MFG-E8 has also gained significant attention because of its wide range of functions in autoimmunity, inflammation and tissue homeostasis. More recently, MFG-E8 has been identified as a critical regulator of bone homeostasis, being expressed in both, osteoblasts and osteoclasts. In addition, it was shown that MFG-E8 fulfils an active role in modulating inflammatory processes, suggesting an anti-inflammatory role of MFG-E8 and proposing it as a novel therapeutic target for inflammatory diseases. This concise review focusses on the expression and regulation of MFG-E8 in the context of inflammatory bone diseases, highlights its role in the pathophysiology of osteoimmune diseases and discusses the therapeutic potential of MFG-E8.
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