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Related Experiment Video

Updated: Mar 15, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Risk Differences Between Prediabetes And Diabetes According To Breast Cancer Molecular Subtypes.

A Crispo1, L S A Augustin1,2, M Grimaldi1

  • 1Unit of Epidemiology, National Cancer Institute, G. Pascale Foundation, Naples, Italy.

Journal of Cellular Physiology
|September 1, 2016
PubMed
Summary
This summary is machine-generated.

Prediabetes and diabetes significantly increase breast cancer risk, particularly in hormone receptor-positive subtypes. These metabolic conditions are strongly linked to higher breast cancer incidence.

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Area of Science:

  • Endocrinology
  • Oncology
  • Metabolic Syndrome

Background:

  • Hyperglycemia and hyperinsulinemia are implicated in breast carcinogenesis.
  • Prediabetes and diabetes are linked to increased breast cancer risk, but subtype-specific associations are unclear.

Purpose of the Study:

  • To investigate the association between prediabetes/diabetes and breast cancer risk.
  • To examine how breast cancer molecular subtypes modify these associations.

Main Methods:

  • Case-control study of 557 non-metastatic breast cancer patients and 592 controls.
  • Multivariate logistic regression models adjusted for known risk factors.
  • Analyses stratified by breast cancer molecular subtypes: Luminal A, Luminal B, HER2+, and Triple Negative.

Main Results:

  • Prediabetes (OR=1.94) and diabetes (OR=2.46) were significantly associated with higher breast cancer incidence.
  • Associations were observed in Luminal A and B subtypes.
  • In Triple Negative breast cancer, only prediabetes showed a significant association (OR=2.43).
  • In HER2+ breast cancer, only diabetes was significant (OR=3.04), particularly in postmenopausal women with hormone receptor-positive status (OR=5.13).

Conclusions:

  • Prediabetes and diabetes are strongly associated with breast cancer incidence.
  • These metabolic conditions appear more relevant for breast cancer subtypes with positive hormone receptors.