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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Zygotic Development And Stem Cell Formation01:10

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Mar 15, 2026

Generation of First Heart Field-like Cardiac Progenitors and Ventricular-like Cardiomyocytes from Human Pluripotent Stem Cells
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Generation of First Heart Field-like Cardiac Progenitors and Ventricular-like Cardiomyocytes from Human Pluripotent Stem Cells

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Probing early heart development to instruct stem cell differentiation strategies.

Damelys Calderon1,2,3, Evan Bardot1,2,3, Nicole Dubois1,2,3

  • 1Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, NY, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|September 1, 2016
PubMed
Summary

Recent discoveries in cardiac progenitor biology are revolutionizing cardiovascular research. Understanding early heart development informs strategies for generating cardiovascular cells for regenerative medicine and treating heart disease.

Keywords:
cardiac maturationcardiac mesodermcardiac progenitorcell fate specificationconduction systemdisease modellingepicardiumgastrulationpluripotent stem cells

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Related Experiment Videos

Last Updated: Mar 15, 2026

Generation of First Heart Field-like Cardiac Progenitors and Ventricular-like Cardiomyocytes from Human Pluripotent Stem Cells
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Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
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Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Cardiovascular Science

Background:

  • Organogenesis, particularly heart development, has been studied for centuries.
  • New discoveries continuously refine our understanding of early cardiac development.
  • Key questions involve the origin and differentiation of cardiac progenitor cells and underlying molecular mechanisms.

Purpose of the Study:

  • To discuss recent discoveries in cardiac progenitor biology.
  • To explore the translation of these discoveries to pluripotent stem cell models.
  • To illustrate how developmental concepts inform regenerative medicine.

Main Methods:

  • Review of current scientific literature on cardiac progenitor biology.
  • Analysis of pluripotent stem cell models in cardiovascular research.
  • Discussion of the impact of developmental concepts on regenerative strategies.

Main Results:

  • Advances in understanding cardiac progenitor cell origins and differentiation potential.
  • Development of efficient strategies for generating cardiovascular cell types ex vivo.
  • Demonstration of the link between developmental biology and regenerative medicine.

Conclusions:

  • Developmental concepts are crucial for advancing regenerative medicine.
  • Efficient generation of cardiovascular cells holds therapeutic potential for heart disease.
  • Continued research in cardiac progenitor biology promises future breakthroughs.