Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.1K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

267
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
267
Regulation of Metabolism01:19

Regulation of Metabolism

12.0K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
12.0K
What is Metabolism?00:52

What is Metabolism?

134.9K
Overview
134.9K
Teratogenicity01:07

Teratogenicity

4.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

312
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
312

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of ABO blood groups and Rh Factor with autism spectrum disorder, down syndrome, and attention deficit hyperactivity disorder among children in the Saudi population.

Pakistan journal of medical sciences·2026
Same author

Impact of social, demographic, and economic factors on fertility trends in South Asia: Longitudinal analysis based on World Bank and Global Burden of Disease Study 1980-2021.

JPMA. The Journal of the Pakistan Medical Association·2026
Same author

Association between learning styles and burnout among medical students: A study at Alfaisal University.

Pakistan journal of medical sciences·2026
Same author

Effect of particulate matter (PM<sub>2.5</sub>, PM<sub>10</sub>) on deaths and disability-adjusted life years (DALYs) in Gulf Cooperation Council countries: Global burden of disease time trend analysis 1990-2021.

Pakistan journal of medical sciences·2025
Same author

Neurocognitive profile of the adult population living with type 1 diabetes mellitus: a matched case-control cross-sectional study of metabolism and memory.

Frontiers in endocrinology·2025
Same author

Effect of climate change, extreme temperatures (heat and cold) on diabetes mellitus risk, hospitalization, and mortality: Global Evidenced Based Study.

Frontiers in public health·2025

Related Experiment Video

Updated: Mar 15, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

11.3K

Metabolic Physiology in Pregnancy.

Sultan Ayoub Meo1, Asim Hassain2

  • 1Department of Physiology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia (KSA).

JPMA. the Journal of the Pakistan Medical Association
|September 2, 2016
PubMed
Summary

Pregnancy triggers unique metabolic shifts, adapting the mother's body for fetal growth and lactation. Disruptions in maternal metabolic physiology can lead to complications like gestational diabetes mellitus.

Keywords:
Pregnancy, Metabolic changes, Physiological changes.

More Related Videos

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

1.5K
A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
11:44

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

11.9K

Related Experiment Videos

Last Updated: Mar 15, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

11.3K
Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

1.5K
A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
11:44

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

11.9K

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Maternal-fetal medicine

Background:

  • Pregnancy involves significant metabolic adaptations for fetal development and maternal readiness for childbirth and lactation.
  • The early gestational period is anabolic, promoting nutrient storage and enhanced insulin sensitivity.
  • The late gestational period is catabolic, characterized by reduced insulin sensitivity.

Purpose of the Study:

  • To elucidate the unique metabolic physiology during pregnancy.
  • To understand the role of the placenta in mediating maternal-fetal metabolic adjustments.
  • To identify potential consequences of disturbed maternal metabolic physiology.

Main Methods:

  • Review of physiological changes during pregnancy.
  • Analysis of hormonal and metabolic shifts.
  • Examination of placental function in metabolic regulation.

Main Results:

  • Pregnancy involves distinct anabolic (early) and catabolic (late) metabolic phases.
  • The placenta acts as a crucial sensor, adapting maternal physiology to fetal needs.
  • Disturbances in maternal metabolism can result in hormonal imbalances and insulin resistance.

Conclusions:

  • Maternal metabolic physiology undergoes critical, dynamic changes throughout pregnancy.
  • Proper metabolic adaptation is essential for successful pregnancy outcomes.
  • Impaired metabolic regulation increases the risk of gestational diabetes mellitus and other complications.