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Genetic Determinants of Type 2 Diabetes in Asians
Q Qi1, X Wang2, G Strizich1
1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
International Journal of Diabetology & Vascular Disease Research
|September 2, 2016
Summary
Type 2 diabetes (T2D) is a global health issue, especially in Asia. Genetic studies show Asian populations have higher T2D incidence and earlier onset, but current genetic variants don't fully explain this susceptibility.
Area of Science:
- Genetics
- Endocrinology
- Public Health
Background:
- Type 2 diabetes (T2D) presents a significant global health challenge, with a particularly high prevalence in Asian populations.
- Asian individuals often develop T2D at younger ages and experience higher incidence rates compared to European populations, even with similar weight gain.
- Genome-wide association studies (GWAS) have identified numerous T2D susceptibility loci, with recent focus on Asian cohorts.
Purpose of the Study:
- To review and compare GWAS findings for T2D in East and South Asian populations against European cohorts.
- To investigate the genetic underpinnings of heightened T2D susceptibility in Asian populations.
Main Methods:
- Review of existing genome-wide association studies (GWAS) data.
- Comparative analysis of T2D susceptibility loci identified in Asian and European populations.
Main Results:
- GWAS in Asian populations have confirmed known T2D susceptibility loci and identified novel ones.
- These novel loci offer new insights into the pathophysiology of T2D.
- Current genetic variants identified through GWAS do not fully account for the increased T2D susceptibility observed in Asians compared to Europeans.
Conclusions:
- Further research into the genetic factors contributing to T2D in Asian populations is essential.
- Understanding these genetic differences is crucial for addressing the T2D epidemic in Asia.
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