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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

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Algorithm of chest wall keloid treatment.

Xiao Long¹, Mingzi Zhang, Yang Wang

¹Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing, China.

|September 2, 2016

Summary

An individualized treatment protocol for chest wall keloids, common in Asian populations, demonstrated high patient and doctor satisfaction. This approach significantly reduced keloid recurrence rates, offering a promising solution for challenging cases.

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Area of Science:

Dermatology
Plastic Surgery
Oncology (Radiotherapy)

Background:

Chest wall keloids are prevalent in Asian populations, often linked to acne or cysts.
Treatment is challenging due to limited local tissue and high recurrence rates.
An individualized protocol is needed for effective chest wall keloid management.

Observation:

445 patients with chest wall keloids underwent treatment using 4 distinct protocols from 2006-2012.
All patients received adjuvant radiotherapy.
Patient and Observer Scar Assessment Scale (POSAS) evaluated treatment outcomes over a 13-month mean follow-up.

Findings:

A low recurrence rate of 0.83% was observed.
POSAS scores showed significant improvement (P < 0.001) post-treatment, indicating high satisfaction among both doctors and patients.
The individualized algorithm led to satisfactory clinical results.

Implications:

This algorithm provides a valuable guide for surgeons treating chest wall keloids.
Tailoring treatment based on keloid size and number improves outcomes.
Effective management strategies are crucial for improving quality of life in patients with keloids.