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Vaccinations

Vaccinations

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

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Cross-reactivity

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Related Experiment Video

Updated: Mar 15, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Acute Demyelinating Events Following Vaccines: A Case-Centered Analysis.

Roger Baxter¹, Edwin Lewis¹, Kristin Goddard¹

¹Northern California Kaiser Permanente Vaccine Study Center, Oakland.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|September 3, 2016

Summary

This summary is machine-generated.

This study found no link between vaccines and transverse myelitis (TM). A possible association between the Tdap vaccine and acute disseminated encephalomyelitis (ADEM) was observed, but with a very low excess risk.

Keywords:

acute disseminated encephalomyelitis immunization transverse myelitis vaccine

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Area of Science:

Neurology
Immunology
Vaccine Safety Research

Background:

Investigated potential links between immunizations and neurological conditions like transverse myelitis (TM) and acute disseminated encephalomyelitis (ADEM).
Previous case reports suggested a possible association, but evidence remained inconclusive.

Observation:

Analyzed data from nearly 64 million vaccine doses within the Vaccine Safety Datalink population.
Employed a case-centered method comparing vaccination timing in TM/ADEM cases versus matched controls.

Findings:

No statistically significant increased risk of TM was found following immunization.
A potential association between the Tdap vaccine and ADEM was identified, with an estimated excess risk of 0.385 cases per million doses.

Implications:

The study provides evidence against a general association between vaccines and TM.
While a possible link between Tdap and ADEM exists, the associated risk is very low, suggesting continued vaccine utility.
Highlights the importance of ongoing vaccine safety surveillance for rare neurological events.