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Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
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Assembly of Cytoskeletal Filaments01:18

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Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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Related Experiment Video

Updated: Mar 15, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Protein Assembly: Versatile Approaches to Construct Highly Ordered Nanostructures.

Quan Luo1, Chunxi Hou1, Yushi Bai1

  • 1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , 2699 Qianjin Street, Changchun 130012, P. R. China.

Chemical Reviews
|September 3, 2016
PubMed
Summary
This summary is machine-generated.

Researchers are exploring protein assembly to create advanced biomaterials inspired by nature. This review covers strategies for manipulating protein self-assembly into nanostructures for diverse applications.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Synthetic Biology

Background:

  • Nature utilizes sophisticated protein assemblies for highly functional biological systems.
  • Mimicking natural protein assembly is a key strategy for developing advanced biomaterials.
  • The field of protein assembly has rapidly advanced, yielding innovative manipulation techniques.

Purpose of the Study:

  • To review recent progress in protein assembly for nanostructure creation.
  • To summarize biotechnological and chemical strategies for directed protein self-assembly.
  • To discuss applications of protein assemblies in functional materials.

Main Methods:

  • Biotechnological strategies for protein manipulation.
  • Chemical strategies for controlling protein self-assembly.
  • Combined biotechnological and chemical approaches.

Main Results:

  • Development of diverse strategies to control protein self-assembly into ordered nanostructures.
  • Creation of functional biomaterials with enhanced properties through protein assembly.
  • Identification of protein assemblies as versatile platforms for material design.

Conclusions:

  • Protein assembly is a powerful tool for understanding biological processes and creating novel materials.
  • Interdisciplinary approaches are crucial for advancing protein assembly research.
  • Emerging applications span nanoscience, material science, and synthetic biology.