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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Upper airway and systemic inflammation in obstructive sleep apnoea
Eugenio Vicente1, Jose M Marin2, Santiago J Carrizo3
1Otorhinolaryngology Dept, Hospital Miguel Servet, Zaragoza, Spain CIBER Enfermedades Respiratorias, Madrid, Spain Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain Both authors contributed equally.
The European Respiratory Journal
|September 3, 2016
Summary
Obstructive sleep apnoea (OSA) involves local pharyngeal inflammation, indicated by elevated biomarkers. Effective OSA treatment reduced these local inflammatory markers, but systemic inflammation markers in plasma remained unchanged.
Area of Science:
- Respiratory Medicine
- Immunology
- Sleep Science
Background:
- Obstructive sleep apnoea (OSA) is linked to pharyngeal inflammation.
- The relationship between local pharyngeal inflammation and systemic inflammation in OSA patients is debated.
Purpose of the Study:
- To investigate the association between local (pharyngeal) and systemic inflammatory biomarkers in OSA patients.
- To assess the impact of effective OSA treatment on these inflammatory markers.
Main Methods:
- Recruited 89 OSA patients, 28 snorers, and 26 healthy controls.
- Collected pharyngeal lavage (PHAL) and plasma samples at baseline and after 1 year.
- Analyzed inflammatory cells (flow cytometry) and cytokines (immunoassay) including IL-6, IL-8, and TNF-α.
Main Results:
- Higher levels of CD4+ T-cells, IL-6, and IL-8 were found in the pharyngeal lavage of OSA patients compared to controls.
- Pharyngeal lavage biomarker levels correlated with the apnoea/hypopnoea index (AHI).
- No significant differences in plasma inflammatory biomarkers were observed between groups, nor a correlation between pharyngeal and plasma markers. Treatment reduced pharyngeal biomarkers but not plasma biomarkers.
Conclusions:
- Patients with OSA exhibit elevated local inflammatory biomarkers in the pharynx.
- Effective OSA treatment, including CPAP or surgery, reduces pharyngeal inflammation.
- Systemic inflammation does not appear to be directly linked to local pharyngeal inflammation in OSA based on this study's findings.
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