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The P4COPD Study: Rationale, Goals and Study Design - Prediction, Prevention, Personalized and Precision Management
Àlvar Agustí1,2,3,4, Xènia Carrizosa-Guerri2,3, Ciro Casanova5
1Pulmonary Department, Respiratory Institute, Clinic Barcelona, Spain.
Open Respiratory Archives
|August 1, 2026
Summary
The P4COPD study investigates gene-environment interactions to predict and prevent chronic obstructive pulmonary disease (COPD) in young adults. Early identification and personalized management strategies aim to promote healthy aging and reduce COPD burden.
Area of Science:
- Pulmonary Medicine
- Genetics
- Environmental Health
Background:
- Chronic obstructive pulmonary disease (COPD) is a significant public health concern.
- Emerging research highlights COPD's origins in early-life gene-environment interactions.
- This understanding creates opportunities for a new Prediction, Prevention, Personalized and Precise (P4) management approach.
Purpose of the Study:
- To investigate the genomic and environmental/lifestyle factors influencing COPD in young adults (18-50 years).
- To compare these determinants with those observed in children, adolescents, and older individuals.
- To assess the feasibility and cost-effectiveness of implementing a P4 COPD strategy in young adults.
Main Methods:
- Leveraging existing cohorts and de novo recruitment from primary care.
- Analyzing demographic, epidemiological, clinical, and physiological data.
- Measuring genetic, epigenetic, and proteomic markers to identify COPD endotypes and biomarkers.
Main Results:
- Results will be contrasted with healthy controls and older COPD patient cohorts.
- Exploration of clinical implementation strategies and health cost implications.
- First results are anticipated in Q3-Q4 2026.
Conclusions:
- Early identification of young individuals at risk for COPD is crucial.
- Establishing a P4 strategy for at-risk youth can promote healthy aging.
- This proactive approach holds significant potential for long-term public health benefits.
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