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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy

Wen Chun Juan1, Wanjin Hong2

  • 1Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore. wcjuan@imcb.a-star.edu.sg.

Genes
|September 3, 2016
PubMed

Insights

The Hippo pathway regulates organ size and cell growth via YAP and TAZ. Targeting this pathway offers potential for regenerative medicine and cancer therapy by controlling YAP/TAZ activity.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Oncology

Background:

  • The Hippo signaling pathway is crucial for organ size control, tumor suppression, and stem cell renewal.
  • YES-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are key downstream effectors negatively regulated by Hippo signaling.
  • YAP and TAZ activate growth-promoting genes by interacting with transcription factors like TEADs.

Purpose of the Study:

  • To review the regulatory mechanisms of the Hippo signaling pathway.
  • To elucidate the role of the Hippo pathway in tissue repair and cancer.
  • To analyze therapeutic strategies targeting the Hippo pathway, YAP, and TAZ for regenerative medicine and oncology.

Main Methods:

  • Literature review of Hippo pathway mechanisms.
  • Analysis of YAP/TAZ roles in regeneration and cancer.
  • Evaluation of therapeutic targeting strategies.

Main Results:

  • The Hippo pathway, through YAP/TAZ, promotes organ regeneration but can drive cancer when dysregulated.
  • Aberrant YAP/TAZ activation is linked to tumor development.
  • Pharmacological inhibition of YAP/TAZ is a potential cancer treatment strategy.

Conclusions:

  • Understanding Hippo pathway regulation is key for therapeutic interventions.
  • Targeting YAP and TAZ offers dual potential in regenerative medicine and cancer therapy.
  • Further research into Hippo pathway modulators is warranted for clinical applications.
Keywords:
Hippo pathwayTEADsYAP/TAZcancerregeneration

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