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[Male contraception - the current state of knowledge]
Zygmynt Zdrojewicz1, Karolina Kasperska2, Marta Lewandowska2
1Medical University of Wrocław, Poland: Department of Endocrinology, Diabetes and Radionuclide Therapy.
Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|September 4, 2016
Summary
New male contraceptive methods are under development, exploring hormonal and non-hormonal options like protein inhibitors and vaccines. These advancements aim to increase male involvement in conscious family planning and contraception.
Area of Science:
- Reproductive biology and endocrinology
- Urology and family planning
Background:
- Current male contraception options (condoms, vasectomy) are limited.
- There is a need for new, effective male contraceptive methods to enhance male involvement in family planning.
Purpose of the Study:
- To review the current state of knowledge on male contraception research.
- To highlight emerging hormonal and non-hormonal contraceptive strategies for men.
Main Methods:
- Review of ongoing clinical trials and research on hormonal contraceptives (testosterone, progestins, androgens).
- Exploration of non-hormonal approaches targeting fertilization (Izumo/Juno proteins), spermatogenesis (BRDT inhibitor JQ1), sperm function, and vas deferens patency (ultrasound, SMA injection).
- Investigation into immunocontraception (vaccines).
Main Results:
- Hormonal contraceptives show high efficacy rates in clinical trials.
- Non-hormonal methods targeting fertilization, spermatogenesis, and sperm motility are promising.
- Novel approaches like vas deferens blockage and immunocontraception are under investigation.
Conclusions:
- Significant progress is being made in developing diverse male contraceptive options.
- Both hormonal and non-hormonal strategies offer potential for effective and reversible male contraception.
- Future research aims to provide men with more conscious family planning choices.
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