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Oxidative stress parameters in localized scleroderma patients.

F Kilinc1, S Sener2, A Akbaş2

  • 1Dermatology Clinic, Ataturk Training and Research Hospital, 06800, Bilkent/Ankara, Turkey. fykilinc@yahoo.com.

Archives of Dermatological Research
|September 5, 2016
PubMed
Summary

Localized scleroderma (morphea) involves increased oxidative stress, indicated by higher total oxidant capacity (TOC) and arylesterase (ARES) activity in patients. These findings suggest oxidative stress plays a role in morphea pathogenesis.

Keywords:
ArylesteraseLocalized sclerodermaOxidative stress

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Area of Science:

  • Dermatology
  • Biochemistry
  • Pathophysiology

Background:

  • Localized scleroderma (LS), or morphea, is a chronic inflammatory skin condition with unclear origins.
  • Oxidative stress is hypothesized to contribute to the development of LS.
  • Understanding the role of oxidative stress is crucial for elucidating morphea pathogenesis.

Purpose of the Study:

  • To investigate the association between morphea lesions and markers of oxidative stress.
  • To compare oxidative stress parameters in LS patients and healthy controls.

Main Methods:

  • Serum samples from 13 LS patients (generalized and plaque types) and 13 healthy controls were analyzed.
  • Measurements included total oxidant capacity (TOC), total antioxidant capacity (TAC), and paroxonase-1 (PON1) enzyme activity (arylesterase - ARES).
  • Oxidative stress index (OSI) was calculated.

Main Results:

  • LS patients exhibited significantly higher TOC levels compared to controls (p < 0.01).
  • ARES activity was significantly elevated in LS patients (p < 0.0001).
  • The oxidative stress index (OSI) was significantly higher in the patient group (p < 0.005).

Conclusions:

  • Oxidative stress appears to be implicated in the pathogenesis of localized scleroderma.
  • Elevated ARES levels in morphea patients may reflect increased oxidative stress and its compensatory reduction.
  • Further research with larger cohorts is warranted to confirm these findings.