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Updated: Mar 15, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Eight new eudesmane- and eremophilane-type sesquiterpenoids from Atractylodes lancea
Kuo Xu1, Zi-Ming Feng1, Ya-Nan Yang1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Abstract:
Phytochemical and pharmacological study on the rhizomes of Atractylodes lancea led to the identification of twenty-one compounds: six new eudesmane-type sesquiterpenoids (1-6), two new eremophilane-type sesquiterpenoids (7, 8), and thirteen known compounds (9-21). These new compounds were elucidated using extensive spectroscopic analyses with experimental and calculated electronic circular dichroism (ECD) for the configurational assignments. Notably, this study was the first report on the isolation of two eremophilane-type sesquiterpenoids (7, 8) from the genus Atractylodes. Compounds 5, 7, and 16 showed potent hepatoprotective activities against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury at a concentration of 10μM (bicyclol as the positive drug).
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