Mitochondrial dysfunction and its impact on diabetic heart
Suresh Kumar Verma1, Venkata Naga Srikanth Garikipati1, Raj Kishore2
1Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Insights
Mitochondrial dysfunction and oxidative stress contribute to diabetes-related heart failure. This review explores these abnormalities and their mechanisms, highlighting a key factor in diabetic cardiovascular complications.
Area of Science:
- Cardiovascular Biology
- Metabolic Disorders
- Mitochondrial Medicine
Background:
- Mitochondrial dysfunction and oxidative stress are implicated in various age-related diseases.
- Cardiovascular diseases, particularly heart failure, are prevalent in diabetic patients, contributing to mortality.
- Diabetic patients exhibit increased heart failure risk, even when accounting for hypertension and coronary artery disease.
Purpose of the Study:
- To review abnormalities in mitochondrial function associated with diabetes.
- To discuss the underlying mechanisms of mitochondrial dysfunction in diabetic cardiovascular complications.
- To highlight the role of oxidative stress in diabetes-related heart failure.
Main Methods:
- Literature review focusing on mitochondrial function and oxidative stress in diabetes.
- Analysis of studies investigating the link between mitochondrial abnormalities and heart failure in diabetic patients.
- Synthesis of evidence on potential mechanisms driving these pathological processes.
Main Results:
- Mitochondrial dysfunction and oxidative stress are significant factors in the pathogenesis of diabetic cardiovascular diseases.
- Imbalances in mitochondrial function contribute to increased heart failure risk in diabetes.
- Evidence suggests a multifactorial basis for diabetic heart failure, with mitochondrial issues playing a crucial role.
Conclusions:
- Mitochondrial dysfunction and oxidative stress are key contributors to heart failure in diabetic individuals.
- Understanding these mechanisms is vital for developing therapeutic strategies for diabetic cardiovascular complications.
- Further research into mitochondrial quality control in diabetes is warranted.
Abstract:
Mitochondrial dysfunction and associated oxidative stress are strongly linked to cardiovascular, neurodegenerative, and age associated disorders. More specifically cardiovascular diseases are common in patients with diabetes and significant contributor to the high mortality rates associated with diabetes. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the actual basis of the increased heart failure risk is multifactorial, increasing evidences suggest that imbalances in mitochondrial function and associated oxidative stress play an important role in this process. This review summarizes these abnormalities in mitochondrial function and discusses potential underlying mechanisms. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases - edited by P. Hemachandra Reddy.
Related Concept Videos
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:27Heart Failure I: Introduction
01:21Myocarditis I: Introduction
01:29Heart Failure II: Pathophysiology
01:30Cardiomyopathy II: Dilated Cardiomyopathy
01:37Mitochondria