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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography.

Alice Y Kim1, Damien C Rodger1, Anoush Shahidzadeh1

  • 1Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California.

American Journal of Ophthalmology
|September 6, 2016
PubMed
Summary
This summary is machine-generated.

Uveitis significantly reduces parafoveal capillary density and complexity, as shown by spectral-domain optical coherence tomography angiography (SD-OCTA). These quantitative measures offer a potential new diagnostic index for uveitis.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Vascular Biology

Background:

  • Uveitis is an inflammatory eye condition that can affect retinal vasculature.
  • Assessing retinal capillary changes in uveitis is crucial for understanding disease progression and impact.

Purpose of the Study:

  • To quantitatively analyze retinal capillary density and morphology in uveitis patients using spectral-domain optical coherence tomography angiography (SD-OCTA).

Main Methods:

  • Cross-sectional study involving healthy and uveitic subjects.
  • SD-OCTA imaging (3x3mm2) centered on the fovea.
  • Semi-automated calculation of skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI) in superficial and deep retinal layers.

Main Results:

  • Uveitic eyes showed significantly lower SD, VD, and FD in parafoveal capillaries across all retinal layers compared to healthy eyes.
  • Significantly reduced SD and VD were observed in the deep retinal layer of subjects with uveitic macular edema.

Conclusions:

  • Quantitative SD-OCTA analysis reveals decreased capillary density and complexity in uveitis.
  • SD-OCTA algorithms are effective in detecting these microvascular changes, suggesting potential as a diagnostic index for uveitis.