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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
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Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography.
Alice Y Kim1, Damien C Rodger1, Anoush Shahidzadeh1
1Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California.
American Journal of Ophthalmology
|September 6, 2016
Summary
Uveitis significantly reduces parafoveal capillary density and complexity, as shown by spectral-domain optical coherence tomography angiography (SD-OCTA). These quantitative measures offer a potential new diagnostic index for uveitis.
Area of Science:
- Ophthalmology
- Medical Imaging
- Vascular Biology
Background:
- Uveitis is an inflammatory eye condition that can affect retinal vasculature.
- Assessing retinal capillary changes in uveitis is crucial for understanding disease progression and impact.
Purpose of the Study:
- To quantitatively analyze retinal capillary density and morphology in uveitis patients using spectral-domain optical coherence tomography angiography (SD-OCTA).
Main Methods:
- Cross-sectional study involving healthy and uveitic subjects.
- SD-OCTA imaging (3x3mm2) centered on the fovea.
- Semi-automated calculation of skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI) in superficial and deep retinal layers.
Main Results:
- Uveitic eyes showed significantly lower SD, VD, and FD in parafoveal capillaries across all retinal layers compared to healthy eyes.
- Significantly reduced SD and VD were observed in the deep retinal layer of subjects with uveitic macular edema.
Conclusions:
- Quantitative SD-OCTA analysis reveals decreased capillary density and complexity in uveitis.
- SD-OCTA algorithms are effective in detecting these microvascular changes, suggesting potential as a diagnostic index for uveitis.
