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Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy

Seher Karsli-Ceppioglu1

  • 1Faculty of Pharmacy, Department of Toxicology, Marmara University, Istanbul, Turkey.

Drug Development Research
|September 6, 2016
PubMed

Insights

Epigenetic drugs show promise for treating psychiatric disorders by targeting gene regulation in the brain. This review explores their potential and mechanisms for conditions like depression and schizophrenia.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Epigenetic mechanisms involve DNA and histone modifications controlling gene expression.
  • These mechanisms are crucial for nervous system development and psychiatric disorder pathophysiology.
  • Epigenetic drugs, such as histone deacetylation and DNA methylation inhibitors, are gaining attention.

Purpose of the Study:

  • To review the therapeutic potential of epigenetic drugs for psychiatric diseases.
  • To elucidate the mechanisms by which these drugs regulate dysfunctional genes in the brain.

Main Methods:

  • This is a review article, synthesizing existing preclinical research.
  • Focuses on epigenetic mechanisms and drug targets relevant to psychiatric disorders.

Main Results:

  • Epigenetic regulation plays a significant role in psychiatric disorders.
  • Epigenetic drugs offer a novel therapeutic avenue for conditions like depression, bipolar disorder, and schizophrenia.

Conclusions:

  • Epigenetic drugs hold considerable promise for the management of psychiatric disorders.
  • Further research is needed to fully understand and optimize their use in treating brain dysfunction.
Keywords:
DNMT inhibitorsHDAC inhibitorsepigeneticspsychiatric diseases

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