Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

5.1K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
5.1K
What is Cancer?02:12

What is Cancer?

15.4K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
15.4K
What is Cancer?02:12

What is Cancer?

5.7K
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia.

Natureยท2026
Same author

Prognostic value of measurable residual disease in high-risk MDS after intensive chemotherapy in HOVON-SAKK studies.

HemaSphereยท2026
Same author

Reduced-intensity reinduction for children and young persons with relapsed acute lymphoblastic leukemia.

Leukemiaยท2026
Same author

Updated consensus guidelines for the diagnosis and management of patients with HCL and HCL variant.

Bloodยท2026
Same author

Venetoclax combinations in untreated CLL: 5-year results and patient-reported outcomes analysis of the CLL13/GAIA trial.

Bloodยท2026
Same author

Censoring imbalances in randomized first-line trials of chronic lymphocytic leukemia.

Leukemia & lymphomaยท2026

Related Experiment Video

Updated: Mar 15, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.8K

Leukemia.

Gunnar Juliusson, Rachael Hough

    Progress in Tumor Research
    |September 6, 2016
    PubMed
    Summary

    Adolescent and young adult (AYA) leukemia presents unique challenges due to age-related disease biology and treatment tolerability. This review focuses on acute lymphoblastic leukemia and acute myeloid leukemia in AYAs.

    Area of Science:

    • Hematology
    • Oncology
    • Pediatric Oncology

    Background:

    • Leukemias are malignant blood and bone marrow disorders.
    • Acute leukemias are most common in adolescents and young adults (AYAs).
    • Chronic myeloid leukemia is less frequent in the AYA population.

    Purpose of the Study:

    • To review the epidemiology, pathophysiology, treatment strategies, and outcomes of leukemia in AYAs.
    • To focus on acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in this age group.

    Main Methods:

    • This is a review chapter.
    • It synthesizes current knowledge on AYA leukemia.

    Main Results:

    • Disease biology can be more aggressive in older AYAs.

    More Related Videos

    Assessment of the Metabolic Profile of Primary Leukemia Cells
    06:21

    Assessment of the Metabolic Profile of Primary Leukemia Cells

    Published on: November 21, 2018

    11.1K
    Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
    10:49

    Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

    Published on: September 18, 2013

    18.7K

    Related Experiment Videos

    Last Updated: Mar 15, 2026

    Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
    09:01

    Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

    Published on: March 26, 2018

    14.8K
    Assessment of the Metabolic Profile of Primary Leukemia Cells
    06:21

    Assessment of the Metabolic Profile of Primary Leukemia Cells

    Published on: November 21, 2018

    11.1K
    Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
    10:49

    Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

    Published on: September 18, 2013

    18.7K
  • Treatment tolerability often decreases with age.
  • Specific challenges exist in AYA leukemia therapy delivery and psychosocial support.

    • Conclusions:

    • AYA leukemia requires tailored approaches considering age-specific factors.
    • Understanding these challenges is crucial for improving outcomes in ALL and AML for AYAs.