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Updated: Mar 15, 2026
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Innovative Use of Existing Public and Private Data Sources for Postmarketing Surveillance of Central Line-Associated
Ying P Tabak1, Richard S Johannes, Xiaowu Sun
1Clinical Research, CareFusion, San Diego, California (Drs Tabak, Johannes, Sun, and Crosby); Harvard Medical School, Boston, Massachusetts (Dr Johannes); and Jason and Jarvis Associates LLC, Hilton Head Island, South Carolina (Dr Jarvis). Ying P. Tabak, PhD, focuses on clinical research at CareFusion in San Diego, California. Richard S. Johannes, MD, MS, is engaged in clinical research at CareFusion in San Diego, California, and is a member of the faculty at Harvard Medical School in Boston, Massachusetts. Xiaowu Sun, PhD, is a clinical researcher at CareFusion in San Diego, California. Cynthia T. Crosby, PhD, works in clinical research at CareFusion in San Diego, California. William R. Jarvis, MD, has more than 35 years of experience in health care epidomiology and infection control. He held a number of leadership positions at the Centers for Disease Control and Prevention for 23 years, and now is president of Jason and Jarvis Associates, LLC, Hilton Head Island, South Carolina.
Abstract:
The Centers for Medicare and Medicaid Services (CMS) Hospital Compare central line-associated bloodstream infection (CLABSI) data and private databases containing new-generation intravenous needleless connector (study NC) use at the hospital level were linked. The relative risk (RR) of CLABSI associated with the study NCs was estimated, adjusting for hospital characteristics. Among 3074 eligible hospitals in the 2013 CMS database, 758 (25%) hospitals used the study NCs. The study NC hospitals had a lower unadjusted CLABSI rate (1.03 vs 1.13 CLABSIs per 1000 central line days, P < .0001) compared with comparator hospitals. The adjusted RR for CLABSI was 0.94 (95% confidence interval: 0.86, 1.02; P = .11).
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