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Updated: Mar 15, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
[Human herpes virus 6 infection in an inmunocompetent patient with carbamazepine-induced DRESS syndrome]
Sergio Álvarez1, Ignacio Delama2, Lucas Navajas-Galimany1
1Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Abstract:
DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is an adverse life-threatening drug reaction characterized by a polymorphous rash associated with fever, lymphadenopathy and multiorgan involvement with eosinophilia. We present the case of an immunocompetent man with DRESS syndrome secondary to carbamazepine, that developed concomitantly meningoencephalitis caused by human herpes virus 6 (HHV-6), and a review of literature. The pathogenic role of HHV-6 in DRESS syndrome remains controversial. Given the diagnostic and possibly prognostic significance of HHV-6, the screening seems to be a good measure to use in the clinical management of these patients.
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