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Updated: Mar 15, 2026
Identification of Plasmodesmal Localization Sequences in Proteins In Planta
Published on: August 15, 2017
A Mutasynthetic Library of Platensimycin and Platencin Analogues
Liao-Bin Dong1, Jeffrey D Rudolf1, Ben Shen1
1Department of Chemistry, ‡Department of Molecular Therapeutics, and §Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute , Jupiter, Florida 33458, United States.
Abstract:
Inactivation of ptmB1, ptmB2, ptmT2, or ptmC in Streptomyces platensis SB12029, a platensimycin (PTM) and platencin (PTN) overproducer, revealed that PTM and PTN biosynthesis features two distinct moieties that are individually constructed and convergently coupled to afford PTM and PTN. A focused library of PTM and PTN analogues was generated by mutasynthesis in the ΔptmB1 mutant S. platensis SB12032. Of the 34 aryl variants tested, 18 were incorporated with high titers.
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