RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7

Area of Science:

• Toxicology
• Chemical Safety Assessment
• Environmental Safety

Background:

• The safety of the material under current usage conditions requires comprehensive evaluation.
• Existing data and read-across approaches are utilized for toxicological assessments.

Purpose of the Study:

• To evaluate the genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, and environmental safety of the material.
• To determine the safety profile of the material for its intended applications.

Main Methods:

• Genotoxicity assays were performed.
• Skin sensitization was assessed using read-across data from 2-butyloctan-1-ol (CAS # 3913-02-8).
• Reproductive and local respiratory toxicity were evaluated using the Threshold of Toxicological Concern (TTC) for Cramer Class I materials.
• Developmental and repeat dose toxicity were assessed using data on the target material.
• Phototoxicity/photoallergenicity was determined via UV spectra analysis.
• Environmental safety was evaluated according to the RIFM Framework.

Main Results:

• The material was found to be non-genotoxic.
• No skin sensitization potential was identified.
• The reproductive and local respiratory toxicity assessments yielded acceptable results based on TTC values.
• Developmental and repeat dose toxicity studies indicated a Margin of Exposure (MOE) greater than 100.
• Phototoxicity/photoallergenicity assessment was completed.
• Environmental safety evaluation was concluded.

Conclusions:

• The material is considered safe for use under current conditions.
• The comprehensive toxicological and environmental safety evaluations support the material's continued application.
• No significant safety concerns were identified across the evaluated endpoints.