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Multidisciplinary Approach to Obesity Management: A Case Report
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Obesity: single house for many evils.

Ashwini Kumar1, Bibhukalyan P Nayak, Awanish Kumar

  • 1Department of Biotechnology, National Institute of Technology (NIT), Raipur, India - drawanishkr@gmail.com.

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Summary
This summary is machine-generated.

Obesity, a rapidly growing metabolic disorder, involves complex lifestyle and genetic factors, leading to numerous health complications. This review details the wide-ranging effects of obesity on multiple organ systems.

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Area of Science:

  • Metabolic disorders
  • Genetics
  • Cell biology

Background:

  • Obesity is recognized by the World Health Organization (WHO) as a rapidly escalating metabolic disorder, comparable to diabetes.
  • It arises from a complex interaction between lifestyle choices and genetic predispositions.
  • Obesity is characterized by adipocyte pathology, involving hypertrophy and hyperplasia, impacting numerous organs.

Purpose of the Study:

  • To provide a detailed review of obesity-related complications.
  • To highlight the multifaceted nature of obesity as a disease.
  • To discuss the physiological changes in adipocytes and their systemic effects.

Main Methods:

  • Literature review focusing on obesity and its associated health issues.
  • Analysis of the role of adipocytes and adipokines in obesity.
  • Synthesis of information on the pathological consequences of obesity.

Main Results:

  • Obesity leads to an inflammatory phenotype in adipocytes, altering adipokine secretion (e.g., decreased adiponectin, increased resistin).
  • This contributes to insulin resistance and other metabolic disturbances.
  • Obesity is linked to cardiovascular disease, stroke, cancer, diabetes, sexual dysfunction, and respiratory problems.

Conclusions:

  • Obesity is a complex disease with widespread health implications.
  • Adipocyte dysfunction and altered adipokine profiles are central to its pathology.
  • Understanding these complications is crucial for managing this global health challenge.