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Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...

Spermatogenesis

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Related Experiment Video

Updated: Mar 15, 2026

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry

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Published on: December 28, 2021

Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction.

Yang Mu¹, Wen-Jie Yan¹, Tai-Lang Yin¹

¹Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Molecular Medicine Reports

|September 8, 2016

Summary

This summary is machine-generated.

Curcumin supplementation improved male rat fertility by counteracting high-fat diet-induced damage. This natural compound reduced testicular dysfunction and apoptosis, offering potential benefits for reproductive health.

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Area of Science:

Reproductive biology and toxicology
Natural product chemistry and pharmacology

Background:

High-fat diets (HFD) are linked to male reproductive dysfunction, impacting spermatogenesis.
Curcumin, a compound from Curcuma longa, exhibits antioxidant, anti-inflammatory, and antitumor properties.

Purpose of the Study:

To investigate the protective effects of curcumin against HFD-induced spermatogenesis dysfunction in male rats.

Main Methods:

Sprague-Dawley rats were fed a HFD for 8 weeks, with or without curcumin treatment.
Evaluated testis-to-body weight ratio, serum hormone levels, and testicular histology.
Assessed expression of apoptosis-related proteins: Fas, Bcl-xl, Bax, and cleaved-caspase-3.

Main Results:

Curcumin treatment attenuated HFD-induced decreases in testis/body weight and normalized hormone levels.
Histological improvements included reduced seminiferous tubule atrophy and increased spermatogenetic and interstitial cells.
Curcumin decreased testicular apoptosis by downregulating Fas, Bax, and cleaved-caspase-3, and upregulating Bcl-xl.

Conclusions:

Curcumin effectively ameliorates high-fat diet-induced spermatogenesis dysfunction in male rats.
The protective mechanism involves the reduction of testicular apoptosis and modulation of related protein expression.