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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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[Extraskeletal osteosarcoma: nosologocal diversity, morphology, differential diagnosis, and features of metastasis].

Arkhiv patologii·2018
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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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[Lymph node metastasis of osteosarcomas].

N V Vasiliev1

  • 1Tomsk Cancer Research Institute, Tomsk, Russia.

Arkhiv Patologii
|September 8, 2016
PubMed
Summary

Lymph node metastasis is rare in osteosarcoma but significantly reduces survival, classifying it as stage IV cancer. Key risk factors include older age, female gender, specific sarcoma types, tumor depth, and larger tumor size.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Lymph node metastasis in osteosarcoma is infrequent, occurring in 4-11% of cases.
  • Detection of lymph node metastases signifies clinical stage IV osteosarcoma.
  • This metastasis is linked to a substantial decrease in patient 5-year survival rates.

Purpose of the Study:

  • To review the incidence, risk factors, and potential mechanisms of lymph node metastasis in osteosarcoma.

Main Methods:

  • Literature review of studies reporting on osteosarcoma lymph node metastasis.
  • Analysis of patient data to identify risk factors.
  • Exploration of proposed pathogenetic mechanisms.

Main Results:

  • Identified risk factors for lymph node metastasis include advanced age (≥64 years), female gender, specific diagnoses (undifferentiated pleomorphic sarcoma, osteosarcoma, chondrosarcoma), deep tumor invasion (muscle, bone), and large primary tumor size (>5 cm).

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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
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Related Experiment Videos

Last Updated: Mar 15, 2026

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Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells
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Conclusions:

  • Lymph node metastasis in osteosarcoma, though uncommon, is a critical prognostic indicator.
  • Mesenchymal-to-epithelial transition is hypothesized as the underlying mechanism for osteosarcoma lymph node spread.