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Published on: May 8, 2018
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Low dose palliative radiotherapy for refractory aggressive lymphoma
Osamu Tanaka1, Masahiko Oguchi2, Takayoshi Iida1
1Department of Radiation Oncology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, Japan.
Summary
Low-dose palliative radiotherapy, particularly 8 Gray single fraction, shows efficacy in treating refractory aggressive lymphoma. This treatment offers a meaningful option with a low incidence of adverse events for local control.
Area of Science:
- Oncology
- Radiation Oncology
- Hematology
Background:
- Limited data exists on palliative radiotherapy for aggressive lymphoma.
- Aggressive lymphoma often requires palliative care due to refractory disease.
Purpose of the Study:
- To evaluate the effectiveness of low-dose palliative radiotherapy in patients with refractory aggressive lymphoma.
- To assess the safety and efficacy of different palliative radiotherapy regimens.
Main Methods:
- Eleven patients with 30 aggressive lymphoma sites received palliative radiotherapy.
- Radiotherapy doses included 8 Gy (single fraction), 6 Gy (single fraction), 4 Gy (single fraction), and 4 Gy (2 fractions).
- Patients had received a median of 4 prior chemotherapy regimens.
Main Results:
- A 45% complete response rate and 36% partial response rate were observed.
- One case of acute gingivitis occurred, requiring no medication.
- Three head sites needed retreatment for persistent discomfort; 27/30 sites did not.
Conclusions:
- Eight Gray single fraction radiotherapy is a viable and effective option for refractory aggressive lymphoma.
- This regimen demonstrates meaningful efficacy with an acceptable adverse event profile for local control.
- 8 Gy single fraction radiotherapy is recommended for refractory aggressive lymphoma management.
