Overweight and Weight Gain Predict Psoriasis Development in a Population-based Cohort

Area of Science:

• Dermatology
• Epidemiology
• Public Health

Background:

• Overweight is a suspected risk factor for psoriasis, but prospective evidence is scarce.
• Understanding the relationship between weight and psoriasis is crucial for prevention strategies.

Purpose of the Study:

• To examine the association between overweight, weight gain, and psoriasis risk.
• To investigate potential synergistic effects of overweight and smoking on psoriasis development.

Main Methods:

• A population-based cohort study of 8,752 individuals followed from 1994 to 2008.
• Multivariable logistic regression analysis was used to assess odds ratios.
• Data included body mass index (BMI), weight gain from age 25, smoking status, and sex.

Main Results:

• A dose-response relationship was observed between higher BMI and increased psoriasis odds, particularly in non-smokers (71% increase at BMI ≥ 30 kg/m²).
• Significant dose-response association between weight gain from age 25 and higher odds of psoriasis in middle age (up to 90% increase).
• No synergistic effect found between overweight and smoking, nor any interaction with sex.

Conclusions:

• Overweight and weight gain are significant, modifiable risk factors for psoriasis.
• These findings highlight the potential for weight management in the primary prevention of psoriasis.